Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …

This review focuses on the remodeling of brain circuitry associated with epilepsy, particularly
in excitatory glutamate and inhibitory GABA systems, including alterations in synaptic …

Many studies show that glucose metabolism in epileptic brain areas can be impaired.
Energy is crucial to maintain normal brain function, including ion and neurotransmitter …

Recent evidences suggest key roles of abnormal neurogenesis and astrogliosis in the
pathogenesis of epilepsy. Alterations in the microenvironment of the stem cell, such as …

The emerging perspective is that seizure-induced damage should be regarded not only as
neuronal loss but as adverse long-term behavioral and cognitive consequences. This …

Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing
an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role …

Epilepsy is a common neurological disorder, affecting patients of all ages, reducing the
quality of life, and associated with several comorbidities. Sleep impairment is a frequent …

Seizures often originate in epileptogenic foci. Between seizures (interictally), these foci and
some of the surrounding tissue often show low signals with 18fluorodeoxyglucose (FDG) …

Purpose: In temporal lobe epilepsy, it remains to be clarified whether hippocampal sclerosis
is the cause or the consequence of epilepsy. We studied the temporal evolution of the …

To better understand the role of inflammatory responses in temporal lobe epilepsy, we
characterized Interleukin1-β (IL1-β), Nuclear Factor-κB (NF-κB), and Cyclooxygenase-2 …