Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements
Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric
genetic studies and limited knowledge of shared causal variants. Leveraging regulatory …
genetic studies and limited knowledge of shared causal variants. Leveraging regulatory …
Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation
Abstract The coronavirus disease 2019 (COVID-19) is an infectious disease that mainly
affects the host respiratory system with~ 80% asymptomatic or mild cases and~ 5% severe …
affects the host respiratory system with~ 80% asymptomatic or mild cases and~ 5% severe …
[HTML][HTML] Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy
HIV-1 establishes a life-long reservoir of virally infected cells which cannot be eliminated by
antiretroviral therapy (ART). Here, we demonstrate a markedly altered viral reservoir profile …
antiretroviral therapy (ART). Here, we demonstrate a markedly altered viral reservoir profile …
methyl-ATAC-seq measures DNA methylation at accessible chromatin
Chromatin features are characterized by genome-wide assays for nucleosome location,
protein binding sites, three-dimensional interactions, and modifications to histones and …
protein binding sites, three-dimensional interactions, and modifications to histones and …
Comprehensive multiomics analyses reveal pervasive involvement of aberrant cohesin binding in transcriptional and chromosomal disorder of cancer cells
J Wang, R Nakato - Iscience, 2023 - cell.com
Chromatin organization, whose malfunction causes various diseases including cancer, is
fundamentally controlled by cohesin. While cancer cells have been found with mutated or …
fundamentally controlled by cohesin. While cancer cells have been found with mutated or …
Tissue-specific patterns of allelically-skewed DNA methylation
While DNA methylation is usually thought to be symmetrical across both alleles, there are
some notable exceptions. Genomic imprinting and X chromosome inactivation are two well …
some notable exceptions. Genomic imprinting and X chromosome inactivation are two well …
Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression
J Lin, Y Wen, J Tang, X Zhang, H Zhang, H Zhu - bioRxiv, 2023 - biorxiv.org
What genomic sequences make conserved genes generate divergent expression in closely
related species, which may have critically driven human evolution, has puzzled researchers …
related species, which may have critically driven human evolution, has puzzled researchers …
Comprehensive enhancer-target gene assignments improve gene set level interpretation of genome-wide regulatory data
Background Revealing the gene targets of distal regulatory elements is challenging yet
critical for interpreting regulome data. Experiment-derived enhancer-gene links are …
critical for interpreting regulome data. Experiment-derived enhancer-gene links are …
Epigenomic map** in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architectures
SUMMARY B-cell lineage acute lymphoblastic leukemia (B-ALL) is comprised of diverse
molecular subtypes and while transcriptional and DNA methylation profiling of B-ALL …
molecular subtypes and while transcriptional and DNA methylation profiling of B-ALL …
Whole-genome map** of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature
JA Nakauma-González, M Rijnders, MTW Noordsij… - Cell Genomics, 2024 - cell.com
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) enzymes
mutate specific DNA sequences and hairpin-loop structures, challenging the distinction …
mutate specific DNA sequences and hairpin-loop structures, challenging the distinction …