Exploring treatment options in cancer: tumor treatment strategies

B Liu, H Zhou, L Tan, KTH Siu, XY Guan - Signal transduction and …, 2024 - nature.com
Traditional therapeutic approaches such as chemotherapy and radiation therapy have
burdened cancer patients with onerous physical and psychological challenges …

Head and neck squamous cell carcinoma

DE Johnson, B Burtness, CR Leemans… - Nature reviews Disease …, 2020 - nature.com
Most head and neck cancers are derived from the mucosal epithelium in the oral cavity,
pharynx and larynx and are known collectively as head and neck squamous cell carcinoma …

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

Neoantigens: promising targets for cancer therapy

N ** reveals mechanisms of dengue and Zika virus pathogenesis
PS Shah, N Link, GM Jang, PP Sharp, T Zhu… - Cell, 2018 - cell.com
Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …

Interpretation of cancer mutations using a multiscale map of protein systems

F Zheng, MR Kelly, DJ Ramms, ML Heintschel, K Tao… - Science, 2021 - science.org
INTRODUCTION Tumor genome sequencing has revealed that, beyond a few commonly
mutated genes, most mutations that affect cancer genomes are rare. To interpret these rare …

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity

DL Swaney, DJ Ramms, Z Wang, J Park, Y Goto… - Science, 2021 - science.org
INTRODUCTION Genome-sequencing efforts over the past decade have profiled the genetic
landscape of thousands of tumors and solidified the concept of cancer as a highly …