Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

The altered metabolic programme of cancer cells facilitates their cell-autonomous
proliferation and survival. In normal cells, signal transduction pathways control core cellular …

Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

It has been widely known that oxidative stress disrupts the balance between reactive oxygen
species (ROS) and the antioxidant system in the body. During pregnancy, the physiological …

Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Cancer is a condition where the body cells multiply in an uncontrollable manner.
Chemoprevention of cancer is a broad term that describes the involvement of external …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …