Structural evolution and dynamics of the p53 proteins
The family of the p53 tumor suppressive transcription factors includes p73 and p63 in
addition to p53 itself. Given the high degree of amino-acid-sequence homology and …
addition to p53 itself. Given the high degree of amino-acid-sequence homology and …
From mutational inactivation to aberrant gain‐of‐function: unraveling the structural basis of mutant p53 oncogenic transition
Various evidence has revealed that mutations in p53 exert activities that go beyond simply
inactivation of wildtype functions but rather elicits downstream interactions that promote …
inactivation of wildtype functions but rather elicits downstream interactions that promote …
Most probable druggable pockets in mutant p53-Arg175His clusters extracted from Gaussian accelerated molecular dynamics simulations
Abstract p53, a tumor suppressor protein, is essential for preventing cancer development.
Enhancing our understanding of the human p53 function and its modifications in …
Enhancing our understanding of the human p53 function and its modifications in …
Network Analysis of Molecular Dynamics Sectors in the p53 Protein
JD Fabry, KM Thayer - ACS omega, 2022 - ACS Publications
Design of allosteric regulators is an emergent field in the area of drug discovery holding
promise for currently untreated diseases. Allosteric regulators bind to a protein in one …
promise for currently untreated diseases. Allosteric regulators bind to a protein in one …
Investigating Conformational dynamics and allostery in the p53 DNA-binding domain using molecular simulations
E Papaleo - Allostery: Methods and Protocols, 2021 - Springer
The p53 tumor suppressor is a multifaceted context-dependent protein, which is involved in
multiple cellular pathways, with the ability to either keep the cells alive or to kill them through …
multiple cellular pathways, with the ability to either keep the cells alive or to kill them through …
Computational investigation of the DNA binding domain of p53: a drive towards novel therapeutics
MP Criddle - 2017 - eprints.soton.ac.uk
Proteins are biopolymeric macromolecules that are integral to the survival of all organisms.
They have a plethora of functions, including structural, transport and storage. A series of 20 …
They have a plethora of functions, including structural, transport and storage. A series of 20 …
[CITATION][C] Machine Learning on the Free Energy Landscape of p53: Analyzing Protein Rescue Using Neural Networks
N Kemal - 2023 - Wesleyan University
[CITATION][C] Target Specific Drug Design with Deep Reinforcement Learning
TB Sternlieb - 2022 - Wesleyan University
[CITATION][C] Computational construction of A P53 tetrameric structure
K Thayer, C Carpenter - MOJ Proteom Bioinform, 2016