The vertebrate vasculature displays high organotypic specialization, with the structure and
function of blood vessels catering to the specific needs of each tissue. A unique feature of …

Abbreviations used in this paper: AJ, adherens junction; BBB, blood–brain barrier; BCSFB,
blood–cerebrospinal fluid barrier; CCM, cerebral cavernous malformation; CNS, central …

Vertebrate organs require locally adapted blood vessels,. The gain of such organotypic
vessel specializations is often deemed to be molecularly unrelated to the process of organ …

Neutrophils and macrophages, as key mediators of inflammation, have defined functionally
important roles in mammalian tissue repair. Although recent evidence suggests that similar …

A regular heartbeat is essential to vertebrate life. In the mature heart, this function is driven
by an anatomically localized pacemaker. By contrast, pacemaking capability is broadly …

The ability to visualize and quantitatively measure dynamic biological processes in vivo and
at high spatiotemporal resolution is of fundamental importance to experimental …

The blood–brain barrier (BBB) is essential for maintaining homeostasis within the central
nervous system (CNS) and is a prerequisite for proper neuronal function. The BBB is …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Endothelial cells play a major part in the regulation of vascular permeability and
angiogenesis. According to their duty to fit the needs of the underlying tissue, endothelial …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …