The roles of orexinergic system (orexin-A, orexin-B) and their receptors (orexin receptor type-
1, orexin receptor type-2) in various physiological processes such as arousal, reward …

Accumulating evidence support the critical role of endogenous orexin system in modulation
of various physiological functions. Among these, regulation of pain and wakefulness have …

Study Design Controlled, repeated-measures, single-blind randomized study. Objectives To
determine the effect of cervical or thoracic manipulation on neurotensin, oxytocin, orexin A …

The orexin system consists of orexin A/hypocretin 1 and orexin B/hypocretin 2, and OX1 and
OX2 receptors. Our previous electrophysiological study showed that orexin A in the rat …

Low back pain (LBP) has become a leading cause of disability worldwide. Astrocyte
activation in the spinal cord plays an important role in the maintenance of latent sensitization …

Background Orexinergic neurons in the lateral hypothalamus (LH) play an important role in
pain modulation. In addition, ventral tegmental area (VTA) is known as a part of descending …

Locus coeruleus (LC) nucleus is involved in noradrenergic descending pain modulation. LC
receives dense orexinergic projections from the lateral hypothalamus. Orexin-A and-B are …

We used a reporter mouse line in which green fluorescent protein (GFP) was inserted into
the orexin-1 receptor (OX 1) locus to systematically map the neuroanatomical distribution of …

The orexin (hypocretin) is one of the hypothalamic neuropeptides that plays a critical role in
some behaviors including feeding, sleep, arousal, reward processing, and drug addiction …

The Hippocampus has a role not only in nociception but also in modulation of pain
perception. In addition, orexinergic neurons present in the lateral hypothalamus (LH) have a …