The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …

The current obesity epidemic poses a major public health issue since obesity predisposes
towards several chronic diseases. BMI and total adiposity are positively correlated with …

Extracellular vesicles are emerging key actors in adipocyte communication. Notably, small
extracellular vesicles shed by adipocytes stimulate fatty acid oxidation and migration in …

Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus.
The characteristic features of diabetic dyslipidemia are a high plasma triglyceride …

Obesity predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease
and ischemic stroke, which are the main causes of cardiovascular hospitalization and …

Insulin resistance occurs in obesity and Type II (non-insulin-dependent) diabetes mellitus,
but it is also a prominent feature of lipodystrophy. Adipose tissue could play a crucial part in …

Angiopoietin-like protein (ANGPTL) 8 has been implicated in metabolic syndrome and
reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied …

Research of the past decade has increased our understanding of the role adipose tissue
plays in health and disease. Adipose tissue is now recognized as a highly active metabolic …

Insulin signalling is uniquely required for storing energy as fat in humans. While de novo
synthesis of fatty acids and triacylglycerol occurs mostly in liver, adipose tissue is the primary …