Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …

Over the past decade, cross-linking mass spectrometry (CLMS) has developed into a robust
and flexible tool that provides medium-resolution structural information. CLMS data provide …

Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

Tissue mechanics drive morphogenesis, but how forces are sensed and transmitted to
control stem cell fate and self-organization remains unclear. We show that a …

When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

Integrative structure determination is a powerful approach to modeling the structures of
biological systems based on data produced by multiple experimental and theoretical …

In recent years, chemical crosslinking of protein complexes and the identification of
crosslinked residues by mass spectrometry (XL-MS; sometimes abbreviated as CX-MS) has …

In the eukaryotic nucleus, DNA is packaged in the form of nucleosomes, each of which
comprises about 147 base pairs of DNA wrapped around a histone protein octamer. The …

Global warming poses a major threat to plant growth and crop production. In some plants,
including Arabidopsis thaliana, elevated temperatures induce a series of morphological and …

Access to DNA within nucleosomes is required for a variety of processes in cells including
transcription, replication and repair. Consequently, cells encode multiple systems that …