The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Astrocytes are the most populous glial subtype and are critical for brain function. Despite
this, historically there have been few studies into the role that they may have in …

Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

The blood–brain barrier is a dynamic multicellular interface that regulates the transport of
molecules between the blood circulation and the brain parenchyma. Proteins and peptides …

Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …

Lipid droplets are fat storage organelles present in most eukaryotic cells. They consist of a
neutral lipid core containing mostly triglycerides and sterol esters and covered by a …

Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays a crucial role catalysing the
hydrolysis of monoglycerides into glycerol and fatty acids. It links the endocannabinoid and …

Microglial cells are recognized as the brain's intrinsic immune cells, mediating actions that
range from the protection against harmful conditions that modify CNS homeostasis, to the …

Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …

Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …