Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …

Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …

Abstract WormBase (www. wormbase. org) is the central repository for the genetics and
genomics of the nematode Caenorhabditis elegans. We provide the research community …

The Enc yclopedia of D NA E lements (ENCODE) Data Coordinating Center has developed
the ENCODE Portal database and website as the source for the data and metadata …

To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile
the transcriptomes of single cells or nuclei, termed sci-RNA-seq (single-cell combinatorial …

Abstract WormBase (https://wormbase. org/) is a mature Model Organism Information
Resource supporting researchers using the nematode Caenorhabditis elegans as a model …

The functional annotation of livestock genomes is crucial for understanding the molecular
mechanisms that underpin complex traits of economic importance, adaptive evolution and …

Spatial localization is a key determinant of cellular fate and behavior, but methods for
spatially resolved, transcriptome-wide gene expression profiling across complex tissues are …

Background JBrowse is a fast and full-featured genome browser built with JavaScript and
HTML5. It is easily embedded into websites or apps but can also be served as a standalone …

Abstract The RNA polymerase II (Pol II) enzyme transcribes all protein-coding and most non-
coding RNA genes and is globally regulated by Mediator—a large, conformationally flexible …