Bone is an extremely complex tissue that provides many essential functions in the body.
Bone tissue engineering holds great promise in providing strategies that will result in …

Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

Mesenchymal stem cells (MSCs) within their native environment of the stem cell niche in
bone receive biochemical stimuli from surrounding cells. These stimuli likely in fluence how …

Osteoclasts are thought to be solely responsible for the removal of bone matrix. However,
we show here that osteocytes can also remove bone matrix by reversibly remodeling their …

It has long been thought that the effectiveness and efficiency of physical therapy would
improve if our understanding of the cell biology/biochemistry that participates in mechanics …

Mechanical cell stretching may be an attractive strategy for the tissue engineering of
mechanically functional tissues. It has been demonstrated that cell growth and differentiation …

Bone mineralization entails two mineralization phases: primary and secondary
mineralization. Primary mineralization is achieved when matrix vesicles are secreted by …

Osteocytes are the most numerous cells in bone, embedded within the mineralized bone
matrix. Their slender cytoplasmic processes form a complex intercellular network. In …

Skeletal development (bone modeling) and its maintenance in post-natal life in response to
local and systemic stimuli (bone remodeling) require coordinated activity among osteoblasts …

Mechanical loads are required for optimal bone mass. One mechanism whereby mechanical
loads are transduced into localized cellular signals is strain‐induced fluid flow through …