Tissue morphogenesis requires the collective, coordinated motion and deformation of a
large number of cells. Vertex model simulations for tissue mechanics have been developed …

The last few decades have witnessed diversified in vitro models to recapitulate the
architecture and function of living organs or tissues and contribute immensely to advances in …

Embryo morphogenesis is impacted by dynamic changes in tissue material properties,
which have been proposed to occur via processes akin to phase transitions (PTs). Here, we …

As animals develop, tissue bending contributes to shape the organs into complex three-
dimensional structures. However, the architecture and packing of curved epithelia remains …

Hydrogels are 3D networks that have a high water content. They have been widely used as
cell carriers and scaffolds in tissue engineering due to their structural similarities to the …

Adherens junctions are tensile structures that couple epithelial cells together. Junctional
tension can arise from cell-intrinsic application of contractility or from the cell-extrinsic forces …

The origin of rigidity in disordered materials is an outstanding open problem in statistical
physics. Previously, a class of 2D cellular models has been shown to undergo a rigidity …

Organogenesis is a self-organizing process of multiple cells in three-dimensional (3D)
space, where macroscopic tissue deformations are robustly regulated by multicellular …

The study of organoids, artificially grown cell aggregates with the functionality and small-
scale anatomy of real organs, is one of the most active areas of research in biology and …

This study demonstrates computational simulations of multicellular deformation coupled with
chemical patterning in the three-dimensional (3D) space. To address these aspects, we …