Fluoropolymers have unique physicochemical properties such as hydrophobicity and
lipophobicity, good chemical stability and bio-inertness, low surface energy and phase …

As a versatile quantification and tracking technology, 19F magnetic resonance imaging (19F
MRI) provides quantitative “hot-spot” images without ionizing radiation, tissue depth limit …

19F-MRI offers unique opportunities to image diseases and track cells and therapeutic
agents in vivo. Herein we report a superfluorinated molecular probe, herein called …

Conspectus Future medicine is primarily aiming at the development of novel approaches for
an early diagnosis of diseases and a personalized therapy for patients. For achieving these …

Fluorine magnetic resonance imaging (19F-MRI) is particularly promising for biomedical
applications owing to the absence of fluorine in most biological systems. However, its use …

To achieve high sensitivity for 19F MRI, a class of novel dendritic molecules with multiple
pseudosymmetrical fluorines was designed and efficiently synthesized. Through iterative …

Chemical shape and size play a critical role in chemistry. The van der Waals (vdW) radius, a
familiar manifold used to quantify size by assuming overlap** spheres, provides rapid …

A practical synthesis of the novel highly fluorinated amino acid Fmoc-perfluoro-tert-butyl
tyrosine was developed. The sequence proceeds in two steps from commercially available …

(2 S, 4 R)-and (2 S, 4 S)-perfluoro-tert-butyl 4-hydroxyproline were synthesized (as Fmoc-,
Boc-, and free amino acids) in 2–5 steps. The key step of each synthesis was a Mitsunobu …

Highly fluorinated amino acids can stabilize proteins and complexes with proteins, via
enhanced hydrophobicity, and provide novel methods for identification of specific molecular …