Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

Abstract Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that induces the
production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and …

Interleukin-12 (IL-12) is a heterodimeric cytokine produced mostly by phagocytic cells in
response to bacteria, bacterial products, and intracellular parasites, and to some degree by …

Adoptive T cell therapy (ACT) refers to the therapeutic use of T cells. T cells genetically
engineered to express chimeric antigen receptors (CAR) constitute the most clinically …

THE MAMMALIAN IMMUNE SYSTEM can be broadly divided into two main arms: innate and
adaptive immunity. As its name implies, the cells and receptors of the innate immune system …

In this study, we describe a novel murine model of chronic intestinal inflammation induced
by the hapten reagent 2, 4, 6-trinitrobenzene sulfonic acid (TNBS). Rectal application of low …

Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Interleukin-12 (IL-12) has an essential role in the interaction between the innate and
adaptive arms of immunity by regulating inflammatory responses, innate resistance to …

P HAGOCYTIC CELLS and natural killer (NK) cells are among the effector cell types of
innate resistance that represent a first line of defense against infections or foreign …

Abstract Interleukin‐12 (IL‐12), a 70‐kDa heterodimeric cytokine composed of covalently
linked p35 and p40 chains, is to date the most critical factor for skewing the immune …