High-throughput single-cell profiling provides an unprecedented ability to uncover the
molecular states of millions of cells. These technologies are, however, destructive to cells …

The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …

Single-cell RNA sequencing allows us to model cellular state dynamics and fate decisions
using expression similarity or RNA velocity to reconstruct state-change trajectories; however …

Human neural organoids, generated from pluripotent stem cells in vitro, are useful tools to
study human brain development, evolution and disease. However, it is unclear which parts …

Spatially resolved transcriptomics technologies provide high-throughput measurements of
gene expression in a tissue slice, but the sparsity of these data complicates analysis of …

Spatial regulation of RNA plays a critical role in gene expression regulation and cellular
function. Understanding spatially resolved RNA dynamics and translation is vital for bringing …

Spatially resolved transcriptomics (SRT) measures mRNA transcripts at thousands of
locations within a tissue slice, revealing spatial variations in gene expression and cell types …

Cell-state density characterizes the distribution of cells along phenotypic landscapes and is
crucial for unraveling the mechanisms that drive diverse biological processes. Here, we …

Tissue makeup relies fundamentally on the cellular microenvironment. Spatial single-cell
genomics allows probing the underlying cellular interactions in an unbiased, scalable …

Cells execute biological functions to support phenotypes such as growth, migration, and
secretion. Complementarily, each function of a cell has resource costs that constrain …