'Need for speed: high throughput'–mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes

RA Shepherd, CA Fihn, AJ Tabag… - Natural Product …, 2025 - pubs.rsc.org
Covering: 2015 to 2024Mass spectrometry (MS)-based methods have been implemented
extensively for enzyme engineering due to their label-free nature, making them suitable for …

Multimodal mass spectrometry imaging for plaque-and region-specific neurolipidomics in an Alzheimer's disease mouse model

TJ Trinklein, SS Rubakhin, S Okyem, SW Croslow… - 2024 - chemrxiv.org
The progressive accumulation of amyloid beta (Aβ) plaques is a hallmark of Alzheimer's
disease (AD). However, the biochemical mechanisms of their formation and the …

Uncovering lipid dynamics in Staphylococcus aureus osteomyelitis using multimodal imaging mass spectrometry

CJ Good, CE Butrico, ME Colley, LN Emmerson… - Cell Chemical …, 2024 - cell.com
Osteomyelitis occurs when Staphylococcus aureus invades the bone microenvironment,
resulting in a bone marrow abscess with a spatially defined architecture of cells and …