SARS-CoV-2 mutations and their impact on diagnostics, therapeutics and vaccines

S Thakur, S Sasi, SG Pillai, A Nag, D Shukla… - Frontiers in …, 2022 - frontiersin.org
With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …

SARS‐CoV‐2, the pandemic coronavirus: Molecular and structural insights

SB Kadam, GS Sukhramani, P Bishnoi… - Journal of basic …, 2021 - Wiley Online Library
The outbreak of a novel coronavirus associated with acute respiratory disease, called
COVID‐19, marked the introduction of the third spillover of an animal coronavirus (CoV) to …

Overview of SARS-CoV-2 genome-encoded proteins

C Bai, Q Zhong, GF Gao - Science China Life Sciences, 2022 - Springer
Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) has spread rapidly
throughout the world. SARS-CoV-2 is an enveloped, plus-stranded RNA virus with a single …

Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y **e, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

Wastewater SARS-CoV-2 monitoring as a community-level COVID-19 trend tracker and variants in Ohio, United States

Y Ai, A Davis, D Jones, S Lemeshow, H Tu, F He… - Science of The Total …, 2021 - Elsevier
The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has resulted in more than 129 million confirm cases. Many health authorities around …

SARS-CoV-2 and the host cell: a tale of interactions

M Pizzato, C Baraldi, G Boscato Sopetto… - Frontiers in …, 2022 - frontiersin.org
The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

S Sun, H Gu, L Cao, Q Chen, Q Ye, G Yang… - Nature …, 2021 - nature.com
There is an urgent need for animal models to study SARS-CoV-2 pathogenicity. Here, we
generate and characterize a novel mouse-adapted SARS-CoV-2 strain, MASCp36, that …

Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort …

N Wanlapakorn, N Suntronwong… - Human vaccines & …, 2022 - Taylor & Francis
In light of intermittent supply shortages of individual vaccines and evidence of rare but
serious adverse events after vaccination, heterologous regimens for COVID-19 vaccines …

SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load

T Mourier, M Shuaib, S Hala, S Mfarrej, F Alofi… - Nature …, 2022 - nature.com
Monitoring SARS-CoV-2 spread and evolution through genome sequencing is essential in
handling the COVID-19 pandemic. Here, we sequenced 892 SARS-CoV-2 genomes …

Evolution of SARS-CoV-2 envelope, membrane, nucleocapsid, and spike structural proteins from the beginning of the pandemic to September 2020: a global and …

P Troyano-Hernáez, R Reinosa, Á Holguín - Viruses, 2021 - mdpi.com
Monitoring acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic diversity and
emerging mutations in this ongoing pandemic is crucial for understanding its evolution and …