Periplasmic chaperones: outer membrane biogenesis and envelope stress

AN Combs, TJ Silhavy - Annual Review of Microbiology, 2024 - annualreviews.org
Envelope biogenesis and homeostasis in gram-negative bacteria are exceptionally intricate
processes that require a multitude of periplasmic chaperones to ensure cellular survival …

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

S Okuda, DJ Sherman, TJ Silhavy, N Ruiz… - Nature Reviews …, 2016 - nature.com
Gram-negative bacteria have a double-membrane cellular envelope that enables them to
colonize harsh environments and prevents the entry of many clinically available antibiotics …

Long wavelength–emissive Ru (II) metallacycle–based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment

Y Xu, C Li, X Ma, W Tuo, L Tu, X Li… - Proceedings of the …, 2022 - National Acad Sciences
Ruthenium (Ru) complexes are developed as latent emissive photosensitizers for cancer
and pathogen photodiagnosis and therapy. Nevertheless, most existing Ru complexes are …

Construction of a 980 nm laser-activated Pt (II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

Y Xu, C Li, J An, X Ma, J Yang, L Luo, Y Deng… - Science China …, 2023 - Springer
Although metal-based chemical agents have demonstrated promising bacteriostatic effects
in phototherapy, their short excitation/emission wavelengths and inadequate phototherapy …

A new antibiotic traps lipopolysaccharide in its intermembrane transporter

KS Pahil, MSA Gilman, V Baidin, T Clairfeuille, P Mattei… - Nature, 2024 - nature.com
Gram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic
membrane is surrounded by an outer membrane that blocks the entry of most antibiotics …

Lipids mediate supramolecular outer membrane protein assembly in bacteria

MN Webby, AO Oluwole, C Pedebos, PG Inns… - Science …, 2022 - science.org
β Barrel outer membrane proteins (OMPs) cluster into supramolecular assemblies that give
function to the outer membrane (OM) of Gram-negative bacteria. How such assemblies form …

Design of a Metallacycle‐Based Supramolecular Photosensitizer for In Vivo Image‐Guided Photodynamic Inactivation of Bacteria

Y Xu, W Tuo, L Yang, Y Sun, C Li, X Chen… - Angewandte …, 2022 - Wiley Online Library
Bacterial infection is one of the greatest threats to public health. In vivo real‐time monitoring
and effective treatment of infected sites through non‐invasive techniques, remain a …

Biosynthesis and export of bacterial lipopolysaccharides

C Whitfield, MS Trent - Annual review of biochemistry, 2014 - annualreviews.org
Lipopolysaccharide molecules represent a unique family of glycolipids based on a highly
conserved lipid moiety known as lipid A. These molecules are produced by most gram …

The bacterial cell envelope

TJ Silhavy, D Kahne, S Walker - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The bacteria cell envelope is a complex multilayered structure that serves to protect these
organisms from their unpredictable and often hostile environment. The cell envelopes of …

De Novo Designed Ru (II) Metallacycle as a Microenvironment‐Adaptive Sonosensitizer and Sonocatalyst for Multidrug‐Resistant Biofilms Eradication

Y Xu, Y Pang, L Luo, A Sharma, J Yang… - Angewandte …, 2024 - Wiley Online Library
Albeit sonodynamic therapy (SDT) has achieved encouraging progress in microbial
sterilization, the scarcity of guidelines for designing highly effective sonosensitizers and the …