After undergoing metabolic reprogramming, tumor cells consume additional glutamine to
produce amino acids, nucleotides, fatty acids, and other substances to facilitate their …

l-asparaginase (ASNase, EC 3.5. 1.1) is an aminohydrolase enzyme with important uses in
the therapeutic/pharmaceutical and food industries. Its main applications are as an …

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a
poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC …

Abstract L-Asparaginase (L-ASNase, EC 3.5. 1.1), an antitumor drug for acute lymphoblastic
leukemia (ALL) therapy, is widely used in the clinical field. Similarly, L-ASNase is also a …

Abstract L-asparaginase (L-ASNase) from microbial sources is a commercially vital enzyme
to treat acute lymphoblastic leukemia. However, the side effects associated with the …

Metabolic differences between normal and cancerous cells have been used as a point of
view for develo** anticancer drugs. Some degrading enzymes of certain amino acids …

Abstract l-Asparaginase is an antileukemic drug long approved for clinical use to treat
childhood acute lymphoblastic leukemia, the most common cancer in this population …

Simple Summary Targeting amino acid metabolism in leukemia therapy presents both
opportunities and challenges. While disrupting amino acid utilization can hinder cancer cell …

L-Asparaginase (L-ASNase is the abbreviation, L-asparagine aminohydrolase, EC 3.5. 1.1)
is an enzyme that is clinically employed as an antitumor agent for the treatment of acute …

Asparaginases (ASNases) are a large and structurally diverse group of enzymes ubiquitous
amongst archaea, bacteria and eukaryotes, that catalyze hydrolysis of asparagine to …