Dynamic EMT: a multi‐tool for tumor progression
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Novel therapeutic strategies: Targeting epithelial–mesenchymal transition in colorectal cancer
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …
[HTML][HTML] Cancer invasion and the microenvironment: plasticity and reciprocity
Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …
molecular determinants adapt and react throughout the progression of the disease. Cancer …
METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
B Yue, C Song, L Yang, R Cui, X Cheng, Z Zhang… - Molecular cancer, 2019 - Springer
Background As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic
development and is viewed as an essential early step in tumour metastasis. We found that …
development and is viewed as an essential early step in tumour metastasis. We found that …
Epithelial–mesenchymal plasticity in carcinoma metastasis
JH Tsai, J Yang - Genes & development, 2013 - genesdev.cshlp.org
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. Metastasis occurs through a series of steps …
site and form secondary tumors at a distant site. Metastasis occurs through a series of steps …
Oncogenic roles of EMT-inducing transcription factors
A Puisieux, T Brabletz, J Caramel - Nature cell biology, 2014 - nature.com
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
U Wellner, J Schubert, UC Burk, O Schmalhofer… - Nature cell …, 2009 - nature.com
Invasion and metastasis of carcinomas is promoted by the activation of the
embryonic'epithelial to mesenchymal transition'(EMT) program, which triggers cellular …
embryonic'epithelial to mesenchymal transition'(EMT) program, which triggers cellular …
MicroRNAs in development and disease
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …
introduced an additional level of intricacy to our understanding of gene regulation. There are …