Elongation factor thermal unstable Tu (EF-Tu) is a G protein that catalyzes the binding of
aminoacyl-tRNA to the A-site of the ribosome inside living cells. Structural and biochemical …

Host infection by a micro-organism triggers systemic inflammation, innate immunity and
complement pathways, but also haemostasis activation. The role of thrombin and fibrin …

Much of what we know regarding bacterial spore structure and function has been learned
from studies of the genetically well-characterized bacterium Bacillus subtilis. Molecular …

The complement and coagulation systems are two related protein cascades in plasma that
serve important roles in host defense and hemostasis, respectively. Complement activation …

In order for invasive pathogens to migrate beyond the site of infection, host physiological
barriers such as the extracellular matrix, the basement membrane, and encapsulating fibrin …

Multiple species of bacteria are able to sequester the host zymogen plasminogen to the cell
surface. Once localised to the bacterial surface, plasminogen can act as a cofactor in …

The humoral serine proteases of the complement system and the coagulation system play
central roles during the events of an inflammatory response. While the complement system …

Clostridium difficile spores are considered the morphotype of infection, transmission and
persistence of C. difficile infections. There is a lack of information on the composition of the …

Bacillus anthracis poly-γ-D-glutamic acid (PGA) capsule is an essential virulent factor that
helps the bacterial pathogen to escape host immunity. Like other encapsulated bacterial …

The human immune system has evolved a variety of mechanisms for the primary task of
neutralizing and eliminating microbial intruders. As the first line of defense, the complement …