Nanomaterials for antiangiogenic therapies for cancer: a promising tool for personalized medicine
Angiogenesis is one of the hallmarks of cancer. Several studies have shown that vascular
endothelium growth factor (VEGF) plays a leading role in angiogenesis progression …
endothelium growth factor (VEGF) plays a leading role in angiogenesis progression …
Platelet-derived growth factor receptor/platelet-derived growth factor (PDGFR/PDGF) system is a prognostic and treatment response biomarker with multifarious …
K Appiah-Kubi, Y Wang, H Qian, M Wu, X Yao, Y Wu… - Tumor Biology, 2016 - Springer
Progress in cancer biology has led to an increasing discovery of oncogenic alterations of the
platelet-derived growth factor receptors (PDGFRs) in cancers. In addition, their …
platelet-derived growth factor receptors (PDGFRs) in cancers. In addition, their …
Sunitinib added to FOLFIRI versus FOLFIRI in patients with chemorefractory advanced adenocarcinoma of the stomach or lower esophagus: a randomized, placebo …
M Moehler, I Gepfner-Tuma, A Maderer… - BMC cancer, 2016 - Springer
Background As a multi-targeted anti-angiogenic receptor tyrosine kinase (RTK) inhibitor
sunitinib (SUN) has been established for renal cancer and gastrointestinal stromal tumors. In …
sunitinib (SUN) has been established for renal cancer and gastrointestinal stromal tumors. In …
Combining multikinase tyrosine kinase inhibitors targeting the vascular endothelial growth factor and cluster of differentiation 47 signaling pathways is predicted to …
Angiogenesis is a critical step in tumor growth, development, and invasion. Nascent tumor
cells secrete vascular endothelial growth factor (VEGF) that significantly remodels the tumor …
cells secrete vascular endothelial growth factor (VEGF) that significantly remodels the tumor …
Kidney-targeted irradiation triggers renal ischemic preconditioning in mice
B Khbouz, F Lallemand, A Cirillo… - American Journal …, 2022 - journals.physiology.org
Renal ischemia-reperfusion (I/R) causes acute kidney injury (AKI). Ischemic preconditioning
(IPC) attenuates I/R-associated AKI. Whole body irradiation induces renal IPC in mice. Still …
(IPC) attenuates I/R-associated AKI. Whole body irradiation induces renal IPC in mice. Still …
Peptide inhibitors of vascular endothelial growth factor A: current situation and perspectives
I Guryanov, T Tennikova, A Urtti - Pharmaceutics, 2021 - mdpi.com
Vascular endothelial growth factors (VEGFs) are the family of extracellular signaling proteins
involved in the processes of angiogenesis. VEGFA overexpression and altered regulation of …
involved in the processes of angiogenesis. VEGFA overexpression and altered regulation of …
[HTML][HTML] Heterogeneity of chemokine cell-surface receptor expression in triple-negative breast cancer
Introduction: Tumor heterogeneity is a well-established concept in cancer research. In this
paper, we examine an additional type of tumor cell heterogeneity-tumor cell-surface receptor …
paper, we examine an additional type of tumor cell heterogeneity-tumor cell-surface receptor …
[HTML][HTML] Quantification of surface-localized and total oxytocin receptor in myometrial smooth muscle cells
Oxytocin acts through the oxytocin receptor (OXTR) to modulate uterine contractility. We
previously identified OXTR genetic variants and showed that, in HEK293T cells, two of the …
previously identified OXTR genetic variants and showed that, in HEK293T cells, two of the …
[HTML][HTML] M2b macrophages protect against myocardial remodeling after ischemia/reperfusion injury by regulating kinase activation of platelet-derived growth factor …
Y Yue, S Huang, H Li, W Li, J Hou, L Luo… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Myocardial injury is a major cause of myocardial remodeling. Macrophages are
important in cardiac repair as a result of their interactions with fibroblasts. As regulatory …
important in cardiac repair as a result of their interactions with fibroblasts. As regulatory …
Dual inhibition of topoisomerase II and tyrosine kinases by the novel bis-fluoroquinolone chalcone-like derivative HMNE3 in human pancreatic cancer cells
YC Ma, ZX Wang, SJ **, YX Zhang, GQ Hu, DT Cui… - PloS one, 2016 - journals.plos.org
Both tyrosine kinase and topoisomerase II (TopII) are important anticancer targets, and their
respective inhibitors are widely used in cancer therapy. However, some combinations of …
respective inhibitors are widely used in cancer therapy. However, some combinations of …