Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Mononuclear non-heme ferrous iron dependent oxygenases and oxidases constitute an
extended enzyme family that catalyze a wide range of oxidation reactions. The largest …

Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

2-Oxoglutarate (2OG) and ferrous iron dependent oxygenases catalyze two-electron
oxidations of a range of small and large molecule substrates, including proteins/peptides …

This chapter summarizes the diverse array of biochemical transformations that are catalysed
by Fe (ii)-and 2-oxoglutarate (2OG, also known as α-ketoglutarate)-dependent oxygenases …

Non-heme iron and α-ketoglutarate (αKG) oxygenases catalyze remarkably diverse
reactions using a single ferrous ion cofactor. A major challenge in studying this versatile …

The vicinal oxygen chelate family of enzymes catalyzes a highly diverse set of chemistries
that derives from one common mechanistic trait: bidentate coordination to a divalent metal …

The number of identified and confirmed α-keto acid dependent oxygenases is increasing
rapidly. All of these enzymes have a relatively simple liganding arrangement for a single …

Covering: up to 2017 2-Oxoglutarate (2OG) dependent oxygenases and the homologous
oxidase isopenicillin N synthase (IPNS) play crucial roles in the biosynthesis of β-lactam ring …

Covering: 1942–2014 Oxidative rearrangements are key reactions during the biosyntheses
of many secondary metabolites in fungi. This review highlights the most important examples …