Extended-spectrum β-lactamases: an update on their characteristics, epidemiology and detection

M Castanheira, PJ Simner… - JAC-antimicrobial …, 2021 - academic.oup.com
Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major
cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the …

Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning?

C Jung, D Kmiec, L Koepke, F Zech, T Jacob… - Journal of …, 2022 - Am Soc Microbiol
Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …

Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus

Y Wan, J Shang, R Graham, RS Baric, F Li - Journal of virology, 2020 - Am Soc Microbiol
ABSTRACT Recently, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China,
causing symptoms in humans similar to those caused by severe acute respiratory syndrome …

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses

J Huerta-Cepas, D Szklarczyk, D Heller… - Nucleic acids …, 2019 - academic.oup.com
Abstract eggNOG is a public database of orthology relationships, gene evolutionary histories
and functional annotations. Here, we present version 5.0, featuring a major update of the …

MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization

K Katoh, J Rozewicki, KD Yamada - Briefings in bioinformatics, 2019 - academic.oup.com
This article describes several features in the MAFFT online service for multiple sequence
alignment (MSA). As a result of recent advances in sequencing technologies, huge numbers …

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

TD Goddard, CC Huang, EC Meng… - Protein …, 2018 - Wiley Online Library
UCSF ChimeraX is next‐generation software for the visualization and analysis of molecular
structures, density maps, 3D microscopy, and associated data. It addresses challenges in …

Protein sequence analysis using the MPI bioinformatics toolkit

F Gabler, SZ Nam, S Till, M Mirdita… - Current Protocols in …, 2020 - Wiley Online Library
Abstract The MPI Bioinformatics Toolkit (https://toolkit. tuebingen. mpg. de) provides
interactive access to a wide range of the best‐performing bioinformatics tools and …

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

T Zhang, C Yin, A Fedorov, L Qiao, H Bao… - Nature, 2022 - nature.com
Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …

Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost

F Muecksch, Z Wang, A Cho, C Gaebler, T Ben Tanfous… - Nature, 2022 - nature.com
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent
individuals,–. Despite the reduced protection from infection, individuals who received three …