The β-barrel assembly machinery in motion
In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins (OMPs) is
mediated by the β-barrel assembly machinery (BAM) complex. During the past decade …
mediated by the β-barrel assembly machinery (BAM) complex. During the past decade …
[HTML][HTML] The Bam machine: a molecular cooper
The bacterial outer membrane (OM) is an exceptional biological structure with a unique
composition that contributes significantly to the resiliency of Gram-negative bacteria. Since …
composition that contributes significantly to the resiliency of Gram-negative bacteria. Since …
Structural insight into the biogenesis of β-barrel membrane proteins
Abstract β-barrel membrane proteins are essential for nutrient import, signalling, motility and
survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is …
survival. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex is …
Structural basis of outer membrane protein insertion by the BAM complex
All Gram-negative bacteria, mitochondria and chloroplasts have outer membrane proteins
(OMPs) that perform many fundamental biological processes. The OMPs in Gram-negative …
(OMPs) that perform many fundamental biological processes. The OMPs in Gram-negative …
Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry
DS Chorev, LA Baker, D Wu, V Beilsten-Edmands… - Science, 2018 - science.org
Membrane proteins reside in lipid bilayers and are typically extracted from this environment
for study, which often compromises their integrity. In this work, we ejected intact assemblies …
for study, which often compromises their integrity. In this work, we ejected intact assemblies …
Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides
Z Ye, L Fu, S Li, Z Chen, J Ouyang, X Shang… - Nature …, 2024 - nature.com
Non-direct antimicrobial cationic peptides (NDACPs) are components of the animal innate
immune system. But their functions and association with antimicrobial peptides (AMPs) are …
immune system. But their functions and association with antimicrobial peptides (AMPs) are …
Structure of a nascent membrane protein as it folds on the BAM complex
Mitochondria, chloroplasts and Gram-negative bacteria are encased in a double layer of
membranes. The outer membrane contains proteins with a β-barrel structure,. β-Barrels are …
membranes. The outer membrane contains proteins with a β-barrel structure,. β-Barrels are …
The structure of the β-barrel assembly machinery complex
J Bakelar, SK Buchanan, N Noinaj - Science, 2016 - science.org
β-Barrel outer membrane proteins (OMPs) are found in the outer membranes of Gram-
negative bacteria and are essential for nutrient import, signaling, and adhesion. A 200 …
negative bacteria and are essential for nutrient import, signaling, and adhesion. A 200 …
Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM
The β-barrel assembly machinery (BAM) is a∼ 203 kDa complex of five proteins (BamA–E),
which is essential for viability in E. coli. BAM promotes the folding and insertion of β-barrel …
which is essential for viability in E. coli. BAM promotes the folding and insertion of β-barrel …
Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins
In Gram-negative bacteria, the assembly of β-barrel outer-membrane proteins (OMPs)
requires the β-barrel–assembly machinery (BAM) complex. We determined the crystal …
requires the β-barrel–assembly machinery (BAM) complex. We determined the crystal …