Major depressive disorder: hypothesis, mechanism, prevention and treatment

L Cui, S Li, S Wang, X Wu, Y Liu, W Yu… - Signal transduction and …, 2024 - nature.com
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

[HTML][HTML] Biological, psychological, and social determinants of depression: a review of recent literature

O Remes, JF Mendes, P Templeton - Brain sciences, 2021 - mdpi.com
Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression

K Zhang, F Wang, M Zhai, M He, Y Hu, L Feng… - …, 2023 - pmc.ncbi.nlm.nih.gov
Background: Depression is a mental disorder that poses a serious threat to human health.
Adult hippocampal neurogenesis (AHN) is closely associated with the efficacy of …

Clinical practice guideline for the assessment and treatment of children and adolescents with major and persistent depressive disorders

HJ Walter, AR Abright, OG Bukstein, J Diamond… - Journal of the American …, 2023 - Elsevier
Objective To enhance the quality of care and clinical outcomes for children and adolescents
with major depressive disorder (MDD) and persistent depressive disorder (PDD). The aims …

Systematic review of gut microbiota and major depression

SG Cheung, AR Goldenthal, AC Uhlemann… - Frontiers in …, 2019 - frontiersin.org
Background: Recently discovered relationships between the gastrointestinal microbiome
and the brain have implications for psychiatric disorders, including major depressive …

Child and adolescent depression: A review of theories, evaluation instruments, prevention programs, and treatments

E Bernaras, J Jaureguizar, M Garaigordobil - Frontiers in psychology, 2019 - frontiersin.org
Depression is the principal cause of illness and disability in the world. Studies charting the
prevalence of depression among children and adolescents report high percentages of …

[HTML][HTML] New atypical antipsychotics in the treatment of schizophrenia and depression

J Orzelska-Górka, J Mikulska, A Wiszniewska… - International Journal of …, 2022 - mdpi.com
Schizophrenia and depression are heterogeneous disorders. The complex
pathomechanism of the diseases imply that medication responses vary across patients …

The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

E Pitsillou, SM Bresnehan, EA Kagarakis… - Molecular biology …, 2020 - Springer
Major depressive disorder (MDD) is considered a serious public health issue that adversely
impacts an individual's quality of life and contributes significantly to the global burden of …

Biological sex differences in depression: a systematic review

A Labaka, O Goñi-Balentziaga… - … research for nursing, 2018 - journals.sagepub.com
Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher
in women than in men. There is, however, a lack of data on sex-specific pathophysiology of …

Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

X Fu, Y Wang, F Zhao, R Cui, W **e, Q Liu… - Aging (Albany …, 2023 - pmc.ncbi.nlm.nih.gov
Depression and obesity are both common disorders currently affecting public health,
frequently occurring simultaneously within individuals, and the relationship between these …