Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Abstract Histone deacetylase 6 (HDAC6) is a critical target for drug design because of its
role in oncogenic transformation and cancer metastasis, and is unique among all histone …

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a
group of targeted anticancer agents. The first of these new HDACi, vorinostat …

Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …

Microtubules have important functions ranging from maintenance of cell morphology to
subcellular transport, cellular signaling, cell migration, and formation of cell polarity. At the …

Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important
biological processes, including cell migration, immune synapse formation, viral infection …

During cell entry, capsids of incoming influenza A viruses (IAVs) must be uncoated before
viral ribonucleoproteins (vRNPs) can enter the nucleus for replication. After hemagglutinin …

Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal
models of neurodegenerative diseases. Such results were mainly associated with the …

Abstract Histone deacetylase 6 (HDAC6), a unique cytoplasmic deacetylase, likely plays a
role in neurodegeneration by coordinating cell responses to abnormal protein aggregation …