Simple Summary Due to the development of high-throughput sequencing technologies,
computational genome annotation of sequences has become one of the principal research …

Biology is going through a paradigm shift from reductionist to holistic, systems-based
approaches. The complete genome sequence for a number of organisms is available and …

The methodologies used to generate genome and metagenome annotations are diverse
and vary between groups and laboratories. Descriptions of the annotation process are …

Abstract BASys (Bacterial Annotation System) is a web server that supports automated, in-
depth annotation of bacterial genomic (chromosomal and plasmid) sequences. It accepts …

Background The function of a novel gene product is typically predicted by transitive
assignment of annotation from similar sequences. We describe a novel method, GOtcha, for …

The prevalent eye disease age-onset cataract is associated with aggregation of human γD-
crystallins, one of the longest-lived proteins. Identification of the γ-crystallin precursors to …

We examine the structural and functional classifications of the protein universe, providing an
overview of the existing classification schemes, their features and inter-relationships. We …

The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for
annotating the molecular function, biological role, and cellular location of gene products in a …

The annotation of protein function at genomic scale is essential for day-to-day work in
biology and for any systematic approach to the modeling of biological systems. Currently …

A prerequisite to systems biology is the integration of heterogeneous experimental data,
which are stored in numerous life-science databases. However, a wide range of obstacles …