The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐
mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are …

Calnexin is a type I integral endoplasmic reticulum (ER) membrane protein with an N-
terminal domain that resides in the lumen of the ER and a C-terminal domain that extends …

Sustaining neuronal proteostasis during the course of our life is a central aspect required for
brain function. The dynamic nature of synaptic composition and abundance is a requisite to …

Glycoprotein synthesis is initiated in the endoplasmic reticulum (ER) lumen upon transfer of
a glycan (Glc 3 Man 9 GlcNAc 2) from a lipid derivative to Asn residues (N-glycosylation). N …

Neuronal proteostasis is maintained by the dynamic integration of different processes that
regulate the synthesis, folding, quality control, and localization of proteins. The endoplasmic …

The palmitoylation of calnexin serves to enrich calnexin on the mitochondria-associated
membrane (MAM). Given a lack of information on the significance of this finding, we have …

Retinal degenerations are a group of clinically and genetically heterogeneous disorders
characterised by progressive loss of vision due to neurodegeneration. The retina is a highly …

Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic
lateral sclerosis (ALS). Protein disulfide isomerases (PDI s) are ER foldases identified as …