Collagen, the most abundant extracellular matrix protein in animal kingdom belongs to a
family of fibrous proteins, which transfer load in tissues and which provide a highly …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Limited motor activity due to the loss of natural structure impedes recovery in patients
suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening the …

Tendon is an intricately organized connective tissue that efficiently transfers muscle force to
the bony skeleton. Its structure, function, and physiology reflect the extreme, repetitive …

Background: Tendon and ligament injuries accounted for 30% of all musculoskeletal
consultations with 4 million new incidences worldwide each year and thus imposed a …

As dense connective tissues connecting bone to muscle and bone to bone, respectively,
tendon and ligament (T/L) arise from the somitic mesoderm, originating in a recently …

Tendons connect muscles to bones, ensuring joint movement. With advanced age, tendons
become more prone to degeneration followed by injuries. Tendon repair often requires …

Mechanical forces are essential to the development and progression of fibrosis, and are
likely to be as important as soluble factors. These forces regulate the phenotype and …

The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

Small leucine‐rich proteoglycans (SLRP s) are involved in a variety of biological and
pathological processes. This review focuses on their regulatory roles in matrix assembly …