Cancer stem cells: Advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G **ao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Natural product/diet-based regulation of macrophage polarization: Implications in treatment of inflammatory-related diseases and cancer

M Ashrafizadeh, AR Aref, G Sethi, YN Ertas… - The Journal of Nutritional …, 2024 - Elsevier
Macrophages are phagocytic cells with important physiological functions, including the
digestion of cellular debris, foreign substances, and microbes, as well as tissue …

Bifidobacterium breve-derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages

Y Li, Q Li, R Yuan, Y Wang, C Guo, L Wang - Theranostics, 2024 - pmc.ncbi.nlm.nih.gov
Aim: To elucidate dynamics and functions in colonic macrophage subsets, and their
regulation by Bifidobacterium breve (B. breve) and its associated metabolites in the initiation …

[HTML][HTML] Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease

Z Shi, X Li, J Chen, Z Dai, Y Zhu, T Wu, Q Liu, H Qin… - Bioactive Materials, 2024 - Elsevier
Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks
and microbial imbalance play critical roles in the development of inflammatory bowel …

Astragalus polysaccharides attenuate chemotherapy-induced immune injury by modulating gut microbiota and polyunsaturated fatty acid metabolism

H Wang, W Zhu, Y Hong, W Wei, N Zheng, X He, Y Bao… - Phytomedicine, 2024 - Elsevier
Background The damage of chemotherapy drugs to immune function and intestinal mucosa
is a common side effect during chemotherapy. Astragalus polysaccharides (APS) exhibit …

Walnut Protein Peptides Ameliorate DSS-Induced Ulcerative Colitis Damage in Mice: An in Silico Analysis and in Vivo Investigation

Z Hong, C Shi, X Hu, J Chen, T Li, L Zhang… - Journal of Agricultural …, 2023 - ACS Publications
Walnut (Juglans regia L.) is a food with food-medicine homology, whose derived protein
peptides have been shown to have anti-inflammatory activity in vitro. However, the effects …

[HTML][HTML] Extracellular vesicles of Bacteroides uniformis induce M1 macrophage polarization and aggravate gut inflammation during weaning

W Tang, Z Ni, Y Wei, K Hou, TG Valencak, H Wang - Mucosal Immunology, 2024 - Elsevier
Weaning process is commonly associated with gastrointestinal inflammation and dysbiosis
of the intestinal microbes. In particular, the impact of gut bacteria and extracellular vesicles …

Development of nanoparticle vaccines utilizing designed Fc-binding homo-oligomers and RBD-Fc of SARS-CoV-2

Y Liang, W **ao, Y Peng, S Zhang, J Dong, J Zhao… - Antiviral Research, 2024 - Elsevier
The Fc-fused receptor binding domain (RBD-Fc) vaccine for SARS-CoV-2 has garnered
significant attention for its capacity to provide effective and specific immune protection …

LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models

AE Shin, K Sugiura, SW Kariuki, DA Cohen… - The Journal of Clinical …, 2025 - jci.org
Colorectal cancer (CRC) remains a leading cause of cancer death due to metastatic spread.
LIN28B is overexpressed in 30% of CRCs and promotes metastasis, yet its mechanisms …

Oral delivery of sodium alginate/chitosan bilayer microgels loaded with Lactobacillus rhamnosus GG for targeted therapy of ulcerative colitis

Y Hu, S Zhu, X Ye, Z Wen, H Fu, J Zhao, M Zhao… - International Journal of …, 2024 - Elsevier
Probiotics regulate intestinal flora balance and enhance the intestinal barrier, which is useful
in preventing and treating colitis. However, they have strict storage requirements. In addition …