Gangliosides in the brain: physiology, pathophysiology and therapeutic applications
Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …
Metabolic dysfunction and oxidative stress in epilepsy
The epilepsies are a heterogeneous group of disorders characterized by the propensity to
experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the …
experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the …
[HTML][HTML] Mechanistic link between vitamin B12 and Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly population,
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …
Ganglioside GM1 and the central nervous system
Z Guo - International Journal of Molecular Sciences, 2023 - mdpi.com
GM1 is one of the major glycosphingolipids (GSLs) on the cell surface in the central nervous
system (CNS). Its expression level, distribution pattern, and lipid composition are dependent …
system (CNS). Its expression level, distribution pattern, and lipid composition are dependent …
Mitochondria, oxidative stress, and temporal lobe epilepsy
Mitochondrial oxidative stress and dysfunction are contributing factors to various
neurological disorders. Recently, there has been increasing evidence supporting the …
neurological disorders. Recently, there has been increasing evidence supporting the …
Anticonvulsant essential oils and their relationship with oxidative stress in epilepsy
Epilepsy is a most disabling neurological disorder affecting all age groups. Among the
various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative …
various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative …
Gut microbiota–bile acid‐vitamin D axis plays an important role in determining oocyte quality and embryonic development
A Li, F Li, W Song, ZL Lei, QQ Sha… - Clinical and …, 2023 - Wiley Online Library
Objective To reveal whether gut microbiota and their metabolites are correlated with oocyte
quality decline caused by circadian rhythm disruption, and to search possible approaches …
quality decline caused by circadian rhythm disruption, and to search possible approaches …
Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice
Gangliosides have been shown to be necessary for β-amyloid (Aβ) binding and
aggregation. GD3 synthase (GD3S) is responsible for biosynthesis of the b-and c-series …
aggregation. GD3 synthase (GD3S) is responsible for biosynthesis of the b-and c-series …
Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis
Mitochondrial oxidative stress and damage have been implicated in the etiology of temporal
lobe epilepsy, but whether or not they have a functional impact on mitochondrial processes …
lobe epilepsy, but whether or not they have a functional impact on mitochondrial processes …
Swimming training prevents pentylenetetrazol‐induced inhibition of Na+, K+‐ATPase activity, seizures, and oxidative stress
Purpose: In the present study we decided to investigate whether physical exercise protects
against the electrographic, oxidative, and neurochemical alterations induced by …
against the electrographic, oxidative, and neurochemical alterations induced by …