Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

Trichuriasis and ascariasis are neglected tropical diseases caused by the gastrointestinal
dwelling nematodes Trichuris trichiura (a whipworm) and Ascaris lumbricoides (a …

Despite the tremendous progress in healthcare sectors, a number of life-threatening
infectious, inflammatory, and autoimmune diseases are continuously challenging mankind …

Organoids are multicellular culture systems that replicate tissue architecture and function,
and are increasingly used as models of viral, bacterial, and protozoan infections. Organoids …

Coevolutionary adaptation between humans and helminths has developed a finely tuned
balance between host immunity and chronic parasitism due to immunoregulation. Given that …

Dientamoeba fragilis is a cosmopolitan intestinal protist colonizing the human gut with
varying prevalence depending on the cohort studied and the diagnostic methods used. Its …

Summary Background Regulatory T cells (Tregs) can alleviate the development of
autoimmune and inflammatory diseases, thereby proposing their role as a new therapeutic …

Atopic dermatitis (AD) is a common skin disease affecting 20% of the population beginning
usually before one year of age. It is associated with the emergence of allergen-specific IgE …

Inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune
response in the gastrointestinal tract. The number of patients with IBD has increased …

Parasitic helminths, comprising the flatworms (tapeworms and flukes) and nematodes
(roundworms), have plagued humans persistently over a considerable period of time. It is …