Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Identifying the structural adaptations that drive the mechanical load-induced growth of skeletal muscle: a sco** review

KW Jorgenson, SM Phillips, TA Hornberger - Cells, 2020 - mdpi.com
The maintenance of skeletal muscle mass plays a critical role in health and quality of life.
One of the most potent regulators of skeletal muscle mass is mechanical loading, and …

[BOOK][B] Science and development of muscle hypertrophy

BJ Schoenfeld - 2020 - books.google.com
Science and Development of Muscle Hypertrophy, Second Edition, is the most
comprehensive resource on muscle hypertrophy in the world. Written by Brad Schoenfeld …

Elevated myonuclear density during skeletal muscle hypertrophy in response to training is reversed during detraining

CM Dungan, KA Murach, KK Frick… - … of Physiology-Cell …, 2019 - journals.physiology.org
Myonuclei gained during exercise-induced skeletal muscle hypertrophy may be long-lasting
and could facilitate future muscle adaptability after deconditioning, a concept colloquially …

Early satellite cell communication creates a permissive environment for long-term muscle growth

KA Murach, BD Peck, RA Policastro, IJ Vechetti… - Iscience, 2021 - cell.com
Using in vivo muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking,
satellite cell depletion, in vitro cell culture, and single-cell RNA sequencing, we show …

Sarcoplasmic hypertrophy in skeletal muscle: a scientific “unicorn” or resistance training adaptation?

MD Roberts, CT Haun, CG Vann, SC Osburn… - Frontiers in …, 2020 - frontiersin.org
Skeletal muscle fibers are multinucleated cells that contain mostly myofibrils suspended in
an aqueous media termed the sarcoplasm. Select evidence suggests sarcoplasmic …

The failed clinical story of myostatin inhibitors against Duchenne muscular dystrophy: exploring the biology behind the battle

E Rybalka, CA Timpani, DA Debruin, RM Bagaric… - Cells, 2020 - mdpi.com
Myostatin inhibition therapy has held much promise for the treatment of muscle wasting
disorders. This is particularly true for the fatal myopathy, Duchenne Muscular Dystrophy …

The utility—and limitations—of the rodent synergist ablation model in examining mechanisms of skeletal muscle hypertrophy

MD Roberts, TA Hornberger… - American Journal of …, 2024 - journals.physiology.org
In this issue, Burke et al. discuss the utility of the rodent synergist ablation (SA) model for
examining mechanisms associated with skeletal muscle hypertrophy. In this invited …

Making mice mighty: recent advances in translational models of load-induced muscle hypertrophy

KA Murach, JJ McCarthy… - Journal of Applied …, 2020 - journals.physiology.org
The ability to genetically manipulate mice allows for gain-and loss-of-function in vivo,
making them an ideal model for elucidating mechanisms of skeletal muscle mass regulation …

Cellular and molecular pathways controlling muscle size in response to exercise

M Attwaters, SM Hughes - The FEBS journal, 2022 - Wiley Online Library
From the discovery of ATP and motor proteins to synaptic neurotransmitters and growth
factor control of cell differentiation, skeletal muscle has provided an extreme model system …