Cancer genomes contain large numbers of somatic mutations but few of these mutations
drive tumor development. Current approaches either identify driver genes on the basis of …

Genomic integrity is continuously threatened by thousands of endogenous and exogenous
damaging factors. To preserve genome stability, cells developed comprehensive DNA …

Supraphysiological MYC levels are oncogenic. Originally considered a typical transcription
factor recruited to E-boxes (CACGTG), another theory posits MYC a global amplifier …

Mortality from breast cancer is almost exclusively a result of tumor metastasis, and lungs are
one of the main metastatic sites. Cancer-associated fibroblasts are prominent players in the …

The MYC transcription factor plays a key role in cell growth control. Enhanced MYC protein
stability has been found to promote tumorigenesis. Thus, understanding how MYC stability is …

Background and Aims PTTG1 is almost undetectable in adult livers but is highly expressed
in hepatocarcinoma. While little is known about its involvement in liver fibrosis, PTTG1 …

Single-layer omics provide limited insight, whereas integrated multi-omics layers allow
understanding of their combined influence on the complex biological process. The …

Introduction: Somatic mutations in cancer are caused by a complex interaction of many
starting and driving factors that work together to create a unique mutational landscape …

Many cancer genomes contain large numbers of somatic mutations, but few of these
mutations drive tumor development. Current approaches to identify cancer driver genes are …

Selective pressures that trigger cancer formation and progression shape the mutational
landscape of somatic mutations in cancer. Given the limits within which cells are regulated, a …