The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

Despite aggressive surgery, radiotherapy and chemotherapy, malignant gliomas remain
uniformly fatal. To progress, these tumours stimulate the formation of new blood vessels …

Diagnostics and therapies have shown evident advances. Tumour surgery, chemotherapy
and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug …

Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated
with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in …

The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled
receptors, and is directly involved in a number of biological processes including …

The anti-tumor activities of some members of the chemokine family are often overcome by
the functions of many chemokines that are strongly and causatively linked with increased …

Background/Objectives: In the Middle East, people consume camel milk regularly as it is
believed to improve immunity against diseases and decrease the risk for cancer. Recently, it …

The importance of cancer stem cells (CSCs) in tumor-initiation has been firmly established in
leukemia and recently reported for a variety of solid tumors. However, the role of CSCs in …

The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …

The chemokine receptor CXCR4 belongs to the large superfamily of G-protein-coupled
receptors, and is directly involved in a number of biological processes including …