[HTML][HTML] Role of primary aging hallmarks in Alzheimer´ s disease

J Zhao, J Huai - Theranostics, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters

H You, B Lu - Biomolecules, 2023 - mdpi.com
The gene encoding brain-derived neurotrophic factor (Bdnf) consists of nine non-coding
exons driven by unique promoters, leading to the expression of nine Bdnf transcripts that …

2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience

A Kumar, SS Karuppagounder, Y Chen, C Corona… - Neuron, 2023 - cell.com
Intermittent fasting (IF) is a diet with salutary effects on cognitive aging, Alzheimer's disease
(AD), and stroke. IF restricts a number of nutrient components, including glucose. 2 …

Revisiting the expression of BDNF and its receptors in mammalian development

EE Esvald, J Tuvikene, CS Kiir, A Avarlaid… - Frontiers in Molecular …, 2023 - frontiersin.org
Brain-derived neurotrophic factor (BDNF) promotes the survival and functioning of neurons
in the central nervous system and contributes to proper functioning of many non-neural …

Differential regulation of the BDNF gene in cortical and hippocampal neurons

EE Esvald, J Tuvikene, A Moistus… - Journal of …, 2022 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin that supports
the survival, differentiation, and signaling of various neuronal populations. Although it has …

An 840 kb distant upstream enhancer is a crucial regulator of catecholamine‐dependent expression of the Bdnf gene in astrocytes

A Avarlaid, EE Esvald, I Koppel, A Parkman… - Glia, 2024 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) plays a fundamental role in the develo** and
adult nervous system, contributing to neuronal survival, differentiation, and synaptic …

Neuronal enhancers fine-tune adaptive circuit plasticity

EC Griffith, AE West, ME Greenberg - Neuron, 2024 - cell.com
Neuronal activity-regulated gene expression plays a crucial role in sculpting neural circuits
that underpin adaptive brain function. Transcriptional enhancers are now recognized as key …

Regulation of Satiety by Bdnf-e2-Expressing Neurons through TrkB Activation in Ventromedial Hypothalamus

P Chu, W Guo, H You, B Lu - Biomolecules, 2023 - mdpi.com
The transcripts for Bdnf (brain-derived neurotrophic factor), driven by different promoters, are
expressed in different brain regions to control different body functions. Specific promoter (s) …

[HTML][HTML] Structural framework to address variant-gene relationship in primary open-angle glaucoma

N Singh, K Kizhatil, D Duraikannu, H Choquet, KS Nair - Vision Research, 2025 - Elsevier
Primary open-angle glaucoma (POAG) is a complex, multifactorial disease leading to
progressive optic neuropathy and irreversible vision loss. Genome-Wide Association …

PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells

C Iannone, Y Kainov, A Zhuravskaya, F Hamid… - Molecular Cell, 2023 - cell.com
Many spliceosomal introns are excised from nascent transcripts emerging from RNA
polymerase II (RNA Pol II). The extent of cell-type-specific regulation and possible functions …