Advances in high-throughput microscopy have enabled the rapid acquisition of large
numbers of high-content microscopy images. Whether by deep learning or classical …

The molecular mechanisms underlying neuronal dysfunction in Alzheimer's disease (AD)
remain uncharacterized. Here, we identify genes, molecular pathways and cellular …

Computational molecular generation methods that generate chemical structures from gene
expression profiles have been actively developed for de novo drug design. However, most …

Molecular mechanisms enabling pathology-induced neuronal dysfunction in Alzheimer's
disease (AD) remain elusive. Here, we use mechanistic computational models to infer the …

Many tools and algorithms are available for analyzing transcriptomics data. These include
algorithms for performing sequence alignment, data normalization and imputation …

Phenotypic screening and, more generally, phenotypic drug discovery (PDD) have proven
their potential to capture novel polypharmacology‐based mechanisms of action (MoA) that …

Abstract Cyanobacterial Harmful Algal Blooms (CyanoHABs) occur when colonies of
photosynthetic bacteria called cyanobacteria grow out of control, usually in warm, nutrient …

Аннотация Введение. Воздействие вредных химических веществ на организм, в том
числе профессионально обусловленное, представляет опасность для здоровья …

Type 2 diabetes (T2D) is a significant risk factor for Alzheimer's disease (AD). Despite
multiple studies reporting this connection, the mechanism by which T2D exacerbates AD is …

Female cancers, which include breast and gynaecological cancers, represent a significant
global health burden for women. Despite advancements in research pertinent to unearthing …