The keloid disorder: heterogeneity, histopathology, mechanisms and models
GC Limandjaja, FB Niessen, RJ Scheper… - Frontiers in cell and …, 2020 - frontiersin.org
Keloids constitute an abnormal fibroproliferative wound healing response in which raised
scar tissue grows excessively and invasively beyond the original wound borders. This …
scar tissue grows excessively and invasively beyond the original wound borders. This …
Potential cellular and molecular causes of hypertrophic scar formation
WM van der Veer, MCT Bloemen, MMW Ulrich… - Burns, 2009 - Elsevier
A scar is an expected result of wound healing. However, in some individuals, and
particularly in burn victims, the wound healing processes may lead to a fibrotic hypertrophic …
particularly in burn victims, the wound healing processes may lead to a fibrotic hypertrophic …
Scarless wound healing: transitioning from fetal research to regenerative healing
AL Moore, CD Marshall, LA Barnes… - Wiley …, 2018 - Wiley Online Library
Since the discovery of scarless fetal skin wound healing, research in the field has expanded
significantly with the hopes of advancing the finding to adult human patients. There are …
significantly with the hopes of advancing the finding to adult human patients. There are …
Insights into the pathophysiology of hypertrophic scars and keloids: how do they differ?
Hypertrophic scars and keloids are firm, raised, erythematous plaques or nodules that
manifest when the cicatrix fails to properly heal. They result from pathologic wound healing …
manifest when the cicatrix fails to properly heal. They result from pathologic wound healing …
Human hypertrophic and keloid scar models: principles, limitations and future challenges from a tissue engineering perspective
LJ van den Broek, GC Limandjaja… - Experimental …, 2014 - Wiley Online Library
Most cutaneous wounds heal with scar formation. Ideally, an inconspicuous normotrophic
scar is formed, but an abnormal scar (hypertrophic scar or keloid) can also develop. A major …
scar is formed, but an abnormal scar (hypertrophic scar or keloid) can also develop. A major …
[HTML][HTML] MicroRNAs as biological regulators in skin disorders
Abstract microRNAs are being investigated as promising therapeutic targets and biomarkers
for different disease conditions. miRNAs serve as essential regulators of cell differentiation …
for different disease conditions. miRNAs serve as essential regulators of cell differentiation …
Human amniotic mesenchymal stem cells to promote/suppress cancer: two sides of the same coin
Cancer is a leading cause of death in both developed and develo** countries, and
because of population growth and aging, it is a growing medical burden worldwide. With …
because of population growth and aging, it is a growing medical burden worldwide. With …
Vascular endothelial growth factor and cutaneous scarring
TA Wilgus - Advances in Wound Care, 2019 - liebertpub.com
Significance: The proangiogenic mediator vascular endothelial growth factor (VEGF) plays
an important role in cutaneous wound repair. Most of the work on VEGF and wound healing …
an important role in cutaneous wound repair. Most of the work on VEGF and wound healing …
[HTML][HTML] Innovative therapies in the treatment of keloids and hypertrophic scars
MH Viera, S Amini, W Valins… - The Journal of clinical and …, 2010 - ncbi.nlm.nih.gov
Keloids and hypertrophic scars are benign fibrous overgrowths of scar tissue, which results
from an abnormal response to trauma. Several therapeutic modalities have been described …
from an abnormal response to trauma. Several therapeutic modalities have been described …
Molecular regulation of tumor angiogenesis and perfusion via redox signaling
Over the past decade, it has become clear that the gene mutations that initiate
carcinogenesis are an inevitable aspect of aging. By age 70, the incidence of cancerous …
carcinogenesis are an inevitable aspect of aging. By age 70, the incidence of cancerous …