Necrotic death as a cell fate
Organismal homeostasis depends on an intricate balance between cell death and renewal.
Early pathologists recognized that this balance could be disrupted by the extensive damage …
Early pathologists recognized that this balance could be disrupted by the extensive damage …
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
Ceramidases catalyze hydrolysis of ceramides to generate sphingosine (SPH), which is
phosphorylated to form sphingosine-1-phosphate (S1P). Ceramide, SPH, and S1P are …
phosphorylated to form sphingosine-1-phosphate (S1P). Ceramide, SPH, and S1P are …
Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
OBJECTIVE Chronic exercise and obesity both increase intramyocellular triglycerides
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …
[HTML][HTML] A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death
TA Taha, TD Mullen, LM Obeid - Biochimica et Biophysica Acta (BBA) …, 2006 - Elsevier
Programmed cell death is an important physiological response to many forms of cellular
stress. The signaling cascades that result in programmed cell death are as elaborate as …
stress. The signaling cascades that result in programmed cell death are as elaborate as …
The nutritional functions of dietary sphingomyelin and its applications in food
Sphingolipids are common structural components of cell membranes and are crucial for cell
functions in physiological and pathophysiological conditions. Sphingomyelin and its …
functions in physiological and pathophysiological conditions. Sphingomyelin and its …
The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death
JR Van Brocklyn, JB Williams - … and Physiology Part B: Biochemistry and …, 2012 - Elsevier
Sphingolipids are components of all eukaryotic cells that play important roles in a wide
variety of biological processes. Ceramides and sphingosine-1-phosphate (S1P) are …
variety of biological processes. Ceramides and sphingosine-1-phosphate (S1P) are …
The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist
KM Eyster - Advances in physiology education, 2007 - journals.physiology.org
Reviews of signal transduction have often focused on the cascades of protein kinases and
protein phosphatases and their cytoplasmic substrates that become activated in response to …
protein phosphatases and their cytoplasmic substrates that become activated in response to …
Intracellular sphingosine releases calcium from lysosomes
D Höglinger, P Haberkant, A Aguilera-Romero… - elife, 2015 - elifesciences.org
To elucidate new functions of sphingosine (Sph), we demonstrate that the spontaneous
elevation of intracellular Sph levels via caged Sph leads to a significant and transient …
elevation of intracellular Sph levels via caged Sph leads to a significant and transient …
Sphingolipids in mitochondria
Sphingolipids are bioactive lipids found in cell membranes that exert a critical role in signal
transduction. In recent years, it has become apparent that sphingolipids participate in …
transduction. In recent years, it has become apparent that sphingolipids participate in …
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
Sphingosine 1-phosphate (S1P) is a polar sphingolipid metabolite that regulates cell
migration, differentiation, survival and complex physiological processes (Bartke and …
migration, differentiation, survival and complex physiological processes (Bartke and …