Abstract Microsampling, a reduced volume (< 50 μl) sampling method has successfully
gained attention at the International Conference on Harmonization (ICH) level. It has been …

Conventional sampling of biological fluids often involves a bulk quantity of samples that are
tedious to collect, deliver and process. Miniaturized sampling approaches have emerged as …

Therapeutic drug monitoring (TDM) is a specialized area of laboratory medicine which
involves the measurement of drug concentrations in biological fluids with the aim of …

Introduction Direct quantification of drug concentrations allows for medication adherence
monitoring (MAM) and therapeutic drug monitoring (TDM). Multiple less invasive methods …

There are few fields of medicine in which the individualisation of medicines is more
important than in the area of oncology. Under‐dosing can have significant ramifications due …

It is widely accepted that cancer, the second leading cause of death, is a morbidity with big
impacts on the global health. In the last few years, chemo-therapeutic treatment continually …

Background Anticancer drugs are notoriously characterized by a low therapeutic index, the
introduction of therapeutic drug monitoring (TDM) in oncologic clinical practice could …

Introduction The use of dried blood spots (DBS) has gained interest in the field of therapeutic
drug monitoring (TDM) due to its potential advantages, such as minimally invasive capillary …

Extraction is responsible for transferring components from solid materials into solvent.
Tedious extraction procedures are usually involved in liquid chromatography-based …

Background: Volumetric absorptive microsampling has emerged as a less invasive
alternative to venous sampling for small-molecule pharmacokinetic studies, but its …