Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease

AR Bourgonje, M Feelisch, KN Faber, A Pasch… - Trends in molecular …, 2020 - cell.com
Inflammatory bowel disease (IBD) is associated with the production of reactive species that
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …

N‐acetylcysteine: a review of clinical usefulness (an old drug with new tricks)

GK Schwalfenberg - Journal of nutrition and metabolism, 2021 - Wiley Online Library
Objective. To review the clinical usefulness of N‐acetylcysteine (NAC) as treatment or
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …

[HTML][HTML] Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets

AR Bourgonje, D Kloska, A Grochot-Przęczek… - Redox Biology, 2023 - Elsevier
Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are intimately associated with inflammation and overproduction of reactive …

Metabolic influences of gut microbiota dysbiosis on inflammatory bowel disease

S Sultan, M El-Mowafy, A Elgaml, TAE Ahmed… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel diseases (IBD) are chronic medical disorders characterized by recurrent
gastrointestinal inflammation. While the etiology of IBD is still unknown, the pathogenesis of …

Exploring the benefits of probiotics in gut inflammation and diarrhea—From an antioxidant perspective

Q Li, T Zheng, H Ding, J Chen, B Li, Q Zhang, S Yang… - Antioxidants, 2023 - mdpi.com
Inflammatory bowel disease (IBD), characterized by an abnormal immune response,
includes two distinct types: Crohn's disease (CD) and ulcerative colitis (UC). Extensive …

Oxidative stress in the pathogenesis of Crohn's disease and the interconnection with immunological response, microbiota, external environmental factors, and …

E Alemany-Cosme, E Sáez-González, I Moret… - Antioxidants, 2021 - mdpi.com
Inflammatory bowel disease (IBD) is a complex multifactorial disorder in which external and
environmental factors have a large influence on its onset and development, especially in …

Antioxidants as protection against reactive oxidative stress in inflammatory bowel disease

S Jarmakiewicz-Czaja, K Ferenc, R Filip - Metabolites, 2023 - mdpi.com
Inflammatory bowel disease (IBD) belongs to a group of chronic diseases characterised by
periods of exacerbation and remission. Despite many studies and observations, its …

Riboflavin Supplementation in Patients with Crohn's Disease [the RISE-UP study]

JZH von Martels, AR Bourgonje… - Journal of Crohn's …, 2020 - academic.oup.com
Abstract Background and Aims Crohn's disease [CD] is characterised by chronic intestinal
inflammation and dysbiosis in the gut. Riboflavin [vitamin B2] has anti-inflammatory …

Oxidative stress markers in inflammatory bowel diseases: systematic review

M Krzystek-Korpacka, R Kempiński, MA Bromke… - Diagnostics, 2020 - mdpi.com
Precise diagnostic biomarker in inflammatory bowel diseases (IBD) is still missing. We
conducted a comprehensive overview of oxidative stress markers (OSMs) as potential …

Serum free thiols predict cardiovascular events and all-cause mortality in the general population: A prospective cohort study

AE Abdulle, AR Bourgonje, LM Kieneker, AM Koning… - BMC medicine, 2020 - Springer
Background Serum free thiols (R-SH, sulfhydryl groups) reliably reflect systemic oxidative
stress. Since serum free thiols are rapidly oxidized by reactive species, systemic oxidative …