In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the
fundamental processes that fuel respiration and mediate cellular energy transduction …

The global diversity of fungi has been estimated between 2 to 11 million species, of which
only about 155 000 have been named. Most fungi are invisible to the unaided eye, but they …

Cellular functions are mediated by protein–protein interactions, and map** the
interactome provides fundamental insights into biological systems. Affinity purification …

Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and alter
gene expression, yet how they regulate transcription remains unknown. We found that STRs …

The molecular machinery that enables life has evolved in water, yet many of the organisms
around us are able to survive even extreme desiccation. Especially remarkable are single …

Synthetic biology enables the design of gene networks to confer specific biological
functions, yet it remains a challenge to rationally engineer a biological trait as complex as …

Clearance of biomolecular condensates by selective autophagy is thought to play a crucial
role in cellular homeostasis. However, the mechanism underlying selective autophagy of …

Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …