Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

Mitochondrial oxidative damage contributes to a range of degenerative diseases.
Consequently, the selective inhibition of mitochondrial oxidative damage is a promising …

The metabolism of aerobic organisms continuously produces reactive oxygen species.
Although potentially toxic, these compounds also function in signaling. One important …

Botrytis cinerea is a significant necrotrophic plant pathogen causing devastating diseases
on more than 500 plant species, especially on fresh fruits and vegetables, resulting in the …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Mitochondria can be a source of reactive oxygen species (ROS) and a target of oxidative
damage during oxidative stress. In this connection, the effect of photodynamic treatment …

Recent deep sequencing data has provided compelling evidence that the spectrum of
somatic point mutations in mitochondrial DNA (mtDNA) in aging tissues lacks G> T …

Alterations in the levels of numerous second messengers are ubiquitous responses to all
stresses that lead to apoptotic or hormetic responses. The sheer number and vast diversity …

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting approximately
1% of the global population, with a higher prevalence in women than in men. Chronic …

Copper-transporting ATPase ATP7A is essential for mammalian copper homeostasis. Loss
of ATP7A activity is associated with fatal Menkes disease and various other pathologies. In …