Recent and compelling investigation has expanded our view of the biological settings in
which the products of nonenzymatic glycation and oxidation of proteins and lipids–the …

Plaque rupture and subsequent thrombotic occlusion of the coronary artery account for as
many as three quarters of myocardial infarctions. The concept of plaque stabilisation …

Epidemic of diabetes, affecting about 3–5% of Western populations, is one of the main
threats to human health in the 21st century (1). Changes in the human environment …

Objectives: The aim of this study was to determine whether oxidative stress is increased in
calcified, stenotic aortic valves and to examine mechanisms that might contribute to …

A recent explosion in the amount of cardiovascular risk has swept across the globe. Primary
prevention is the preferred method to lower cardiovascular risk. Lowering the prevalence of …

This study was to create a long‐term rabbit model of diabetes mellitus for medical studies of
up to one year or longer and to evaluate the effects of chronic hyperglycemia on damage of …

Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple
genetic and environmental factors. Advances in techniques of molecular genetics have …

Diabetic retinopathy (DR) is a common microvascular complication in patients with diabetes
mellitus. DR is caused by chronic hyperglycemia and characterized by progressive loss of …

No mouse model is currently available where the induction of type 2 diabetes on an
atherosclerotic background could be achieved without significant concomitant changes in …

The vascular endothelial growth factor (VEGF) family plays a major role in tumors and
ophthalmic diseases. However, increasingly more data reported its potential in regulating …