Linking interindividual variability in brain structure to behaviour

S Genon, SB Eickhoff, S Kharabian - Nature Reviews Neuroscience, 2022 - nature.com
What are the brain structural correlates of interindividual differences in behaviour? More
than a decade ago, advances in structural MRI opened promising new avenues to address …

Functional neuroimaging as a catalyst for integrated neuroscience

ES Finn, RA Poldrack, JM Shine - Nature, 2023 - nature.com
Functional magnetic resonance imaging (fMRI) enables non-invasive access to the awake,
behaving human brain. By tracking whole-brain signals across a diverse range of cognitive …

Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety

L Tozzi, X Zhang, A Pines, AM Olmsted, ES Zhai… - Nature medicine, 2024 - nature.com
There is an urgent need to derive quantitative measures based on coherent neurobiological
dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We …

Reproducible brain-wide association studies require thousands of individuals

S Marek, B Tervo-Clemmens, FJ Calabro, DF Montez… - Nature, 2022 - nature.com
Magnetic resonance imaging (MRI) has transformed our understanding of the human brain
through well-replicated map** of abilities to specific structures (for example, lesion …

The promise of machine learning in predicting treatment outcomes in psychiatry

AM Chekroud, J Bondar, J Delgadillo… - World …, 2021 - Wiley Online Library
For many years, psychiatrists have tried to understand factors involved in response to
medications or psychotherapies, in order to personalize their treatment choices. There is …

[HTML][HTML] An overview of clustering methods with guidelines for application in mental health research

CX Gao, D Dwyer, Y Zhu, CL Smith, L Du, KM Filia… - Psychiatry …, 2023 - Elsevier
Cluster analyzes have been widely used in mental health research to decompose inter-
individual heterogeneity by identifying more homogeneous subgroups of individuals …

Distinct symptom-specific treatment targets for circuit-based neuromodulation

SH Siddiqi, SF Taylor, D Cooke… - American Journal of …, 2020 - psychiatryonline.org
Objective: Treatment of different depression symptoms may require different brain
stimulation targets with different underlying brain circuits. The authors sought to identify such …

Functional neuroimaging in psychiatry and the case for failing better

MM Nour, Y Liu, RJ Dolan - Neuron, 2022 - cell.com
Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …

The future of rodent models in depression research

A Gururajan, A Reif, JF Cryan, DA Slattery - Nature Reviews …, 2019 - nature.com
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …