Potential key pathophysiological participant and treatment target in autism spectrum disorder: Microglia
Z Tan, R **a, X Zhao, Z Yang, H Liu, W Wang - Molecular and Cellular …, 2024 - Elsevier
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized
by social and communication deficits, as well as restricted or repetitive behaviors or …
by social and communication deficits, as well as restricted or repetitive behaviors or …
Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder
J Long, H Li, Y Liu, X Liao, Z Tang, K Han… - Frontiers in …, 2024 - frontiersin.org
The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD).
Individuals with ASD typically have impairments in hippocampus-dependent learning …
Individuals with ASD typically have impairments in hippocampus-dependent learning …
TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages
X Chen, Y Zhao, Y Huang, K Zhu, F Zeng, J Zhao… - Glia, 2023 - Wiley Online Library
Triggering receptor expressed on myeloid cell 2 (TREM2), a myeloid cell‐specific signaling
molecule, controls essential functions of microglia and impacts on the pathogenesis of …
molecule, controls essential functions of microglia and impacts on the pathogenesis of …
SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury
Y Qian, L Yang, J Chen, C Zhou, N Zong… - Journal of …, 2024 - Springer
Background Microglia is the major contributor of post-stroke neuroinflammation cascade and
the crucial cellular target for the treatment of ischemic stroke. Currently, the endogenous …
the crucial cellular target for the treatment of ischemic stroke. Currently, the endogenous …
Sex-specific effects of subchronic NMDA receptor antagonist MK-801 treatment on hippocampal gamma oscillations
TS Neuhäusel, Z Gerevich - Frontiers in Neuroscience, 2024 - frontiersin.org
N-methyl-D-aspartate (NMDA) receptor antagonists are widely used to pharmacologically
model schizophrenia and have been recently established in the treatment of treatment …
model schizophrenia and have been recently established in the treatment of treatment …
Towards understanding sex differences in autism spectrum disorders
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized
by social deficits, repetitive behaviours and lack of empathy. Its significant genetic heritability …
by social deficits, repetitive behaviours and lack of empathy. Its significant genetic heritability …
From synapses to circuits: What mouse models have taught us about how autism spectrum disorder impacts hippocampal function
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that impacts a
variety of cognitive and behavioral domains. While a genetic component of ASD has been …
variety of cognitive and behavioral domains. While a genetic component of ASD has been …
Glial cells are affected more than interneurons by the loss of Engrailed 2 gene in the mouse cerebellum
G Lazzarini, A Gatta, V Miragliotta, F Vaglini… - Journal of …, 2024 - Wiley Online Library
Glial cells play a pivotal role in the inflammatory processes, which are common features of
several neurodevelopmental and neurodegenerative disorders. Their major role in …
several neurodevelopmental and neurodegenerative disorders. Their major role in …
Role of MARK2 in the nervous system and cancer
Y Lei, R Zhang, F Cai - Cancer Gene Therapy, 2024 - nature.com
Abstract Microtubule-Affinity Regulating Kinase 2 (MARK2), a member of the
serine/threonine protein kinase family, phosphorylates microtubule-associated proteins …
serine/threonine protein kinase family, phosphorylates microtubule-associated proteins …
Autism Spectrum Disorder: Brain Areas Involved, Neurobiological Mechanisms, Diagnoses and Therapies
J Lamanna, J Meldolesi - International Journal of Molecular Sciences, 2024 - mdpi.com
Autism spectrum disorder (ASD), affecting over 2% of the pre-school children population,
includes an important fraction of the conditions accounting for the heterogeneity of autism …
includes an important fraction of the conditions accounting for the heterogeneity of autism …