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Advances in antibody-based therapy in oncology
Monoclonal antibodies are a growing class of targeted cancer therapeutics, characterized by
exquisite specificity, long serum half-life, high affinity and immune effector functions. In this …
exquisite specificity, long serum half-life, high affinity and immune effector functions. In this …
Virus-like particle vaccinology, from bench to bedside
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …
The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
OX40L-expressing M1-like macrophage exosomes for cancer immunotherapy
With only limited clinical patient benefit, focusing on new immune checkpoint pathways
could be an important complement to current immune checkpoint drugs. In addition, not only …
could be an important complement to current immune checkpoint drugs. In addition, not only …
Strategies and challenges for the next generation of antibody–drug conjugates
Antibody–drug conjugates (ADCs) are one of the fastest growing classes of oncology
therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) …
therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) …
Aptamer-based targeted therapy
Precision medicine holds great promise to harness genetic and epigenetic cues for targeted
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …
[HTML][HTML] Engineering phage host-range and suppressing bacterial resistance through phage tail fiber mutagenesis
The rapid emergence of antibiotic-resistant infections is prompting increased interest in
phage-based antimicrobials. However, acquisition of resistance by bacteria is a major issue …
phage-based antimicrobials. However, acquisition of resistance by bacteria is a major issue …
Single-molecule plasmon sensing: current status and future prospects
Single-molecule detection has long relied on fluorescent labeling with high quantum-yield
fluorophores. Plasmon-enhanced detection circumvents the need for labeling by allowing …
fluorophores. Plasmon-enhanced detection circumvents the need for labeling by allowing …
Design and production of bispecific antibodies
With the current biotherapeutic market dominated by antibody molecules, bispecific
antibodies represent a key component of the next-generation of antibody therapy. Bispecific …
antibodies represent a key component of the next-generation of antibody therapy. Bispecific …
Polymeric microneedles for transdermal protein delivery
The intrinsic properties of therapeutic proteins generally present a major impediment for
transdermal delivery, including their relatively large molecule size and susceptibility to …
transdermal delivery, including their relatively large molecule size and susceptibility to …