Role of monoamine oxidase activity in Alzheimer's disease: an insight into the therapeutic potential of inhibitors

T Behl, D Kaur, A Sehgal, S Singh, N Sharma… - Molecules, 2021 - mdpi.com
Despite not being utilized as considerably as other antidepressants in the therapy of
depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in …

A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review

S Manzoor, N Hoda - European journal of medicinal chemistry, 2020 - Elsevier
Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …

Recent progress in chemosensors based on pyrazole derivatives

A Tigreros, J Portilla - RSC advances, 2020 - pubs.rsc.org
Colorimetric and fluorescent probes based on small organic molecules have become
important tools in modern biology because they provide dynamic information concerning the …

Monoamine oxidases (MAOs) as privileged molecular targets in neuroscience: research literature analysis

AWK Yeung, MG Georgieva, AG Atanasov… - Frontiers in molecular …, 2019 - frontiersin.org
Background: Monoamine oxidases (MAOs) were discovered nearly a century ago. This
article aims to analyze the research literature landscape associated with MAOs as privileged …

Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors

P Guglielmi, B Mathew, D Secci, S Carradori - European Journal of …, 2020 - Elsevier
In the last years the continuous efforts in the development of novel and effective inhibitors of
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …

Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies

A Kumar, M Bhatia, A Kapoor, P Kumar… - European Journal of …, 2022 - Elsevier
Monoamine oxidase enzyme is necessary for the management of brain functions. It
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …

Monoamine oxidase B inhibitors based on natural privileged scaffolds: A review of systematically structural modification

Y Lv, Z Zheng, R Liu, J Guo, C Zhang, Y **e - International Journal of …, 2023 - Elsevier
Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …

Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer's Disease

B Kumar, AR Dwivedi, T Arora, K Raj… - ACS Chemical …, 2022 - ACS Publications
Alzheimer's disease (AD), a multifactorial complex neural disorder, is categorized with
progressive memory loss and cognitive impairment as main clinical features. The multitarget …

Dual-Target Inhibitors Based on Acetylcholinesterase: Novel Agents for Alzheimer's Disease

X Zhao, Q Hu, X Wang, C Li, X Chen, D Zhao… - European Journal of …, 2024 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia among the elderly,
accounting for 60% to 70% of cases. At present, the pathogenesis of this condition remains …

Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure‐Activity Relationships

RR Kumar, B Sahu, S Pathania, PK Singh… - …, 2021 - Wiley Online Library
Depression is the single largest contributor to global disability with a huge economic and
social burden on the world. There are a number of antidepressant drugs on the market, but …